• Rebuilding Nature. Rebuilding Life.

  • Rebuilding Nature. Rebuilding Life.

  • Rebuilding Nature. Rebuilding Life.

  • Rebuilding Nature. Rebuilding Life.



Flagellin phase-dependent swimming on epithelial cell surfaces contributes to productive Salmonella gut colonisation. Horstmann JA et al., 2017, Cell Microbiol.



Proliferation status defines functional properties of endothelial cells. Lipps C et al., 2017, Cell Mol Life Sci.



Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies. Pérez-Campo FM et al., 2017, J Bone Miner Metab.



Human Alveolar Epithelial Cells Expressing Tight Junctions to Model the Air-Blood Barrier. Kuehn A et al., ALTEX. 2016; 33(3):251-60



IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3. Kesselring R et al., 2016, Cancer Cell.



Type 1 fimbriae are important factors limiting the dissemination and colonization of mice by Salmonella Enteritidis and contribute to the induction of intestinal inflammation during Salmonella invasion. Kuzminska-Bajor et al., 2015, Front. Microbiol.



Endothelial cell spheroids as a versatile tool to study angiogenesis in vitro. Heiss et al., 2015, The FASEB Journal.



Generation of Mouse Small Intestinal Epithelial Cell Lines That Allow the Analysis of Specific Innate Immune Functions. Johannes Schwerk, Mario Köster, Hansjörg Hauser, Manfred Rohde, Marcus Fulde, Mathias W. Hornef, Tobias May. PLOS One 2013

Eternity and functionality - rational access to physiologically relevant cell lines. Lipps C, May T, Hauser H, Wirth D. Biol Chem. 2013 Dec;394(12):1637-48.

Hepatitis C Virus Replication in Mouse Cells Is Restricted by IFN-Dependent and -Independent Mechanisms. Ramya Nandakumar, Katja Finsterbusch, Christoph Lipps, Berit Neumann, Martina Grashoff, Sharmila Nair, Inga Hochnadel, Stefan Lienenklaus, Ilka Wappler, Eike Steinmann, Hansjörg Hauser, Thomas Pietschmann, Andrea Kröger. Gastroenterology 2013


Genetic aspects of cell line development from a synthetic biology perspective. Botezatu L, Sievers S, Gama-Norton L, Schucht R, Hauser H, Wirth D. Adv Biochem Eng Biotechnol. 2012

Funktionale Zelllinien durch neue Immortalisierungsprotokolle. May, T., Hauser, H., Wirth, D. BioSpektrum 2012 Volume 18, Issue 4, June 2012, Pages 390-393


Rapid establishment of g-protein-coupled receptor-expressing cell lines by site-specific integration.Schucht R, Lydford S, Andzinski L, Zauers J, Cooper J, Hauser H, Wirth D, May T. J Biomol Screen. 2011

Integrated strategy for the production of therapeutic retroviral vectors. Carrondo M, Panet A, Wirth D, Coroadinha AS, Cruz P, Falk H, Schucht R, Dupont F, Geny-Fiamma C, Merten OW, Hauser H.Hum Gene Ther. 2011

up to 2010

Retroviral vector performance in defined chromosomal Loci of modular packaging cell lines. Gama-Norton L, Herrmann S, Schucht R, Coroadinha AS, Löw R, Alves PM, Bartholomae CC, Schmidt M, Baum C, Schambach A, Hauser H, Wirth D. Hum Gene Ther. 2010

Recombinant protein expression by targeting pre-selected chromosomal loci. Nehlsen K, Schucht R, da Gama-Norton L, Krömer W, Baer A, Cayli A, Hauser H, Wirth D.BMC Biotechnol. 2009

Precise regulation of transgene expression level and control of cell physiology. Schucht R, Wirth D, May T. Cell Biol Toxicol. 2009

Road to precision: recombinase-based targeting technologies for genome engineering. Wirth D, Gama-Norton L, Riemer P, Sandhu U, Schucht R, Hauser H. Curr Opin Biotechnol. 2007

A new generation of retroviral producer cells: predictable and stable virus production by Flp-mediated site-specific integration of retroviral vectors. Schucht R, Coroadinha AS, Zanta-Boussif MA, Verhoeyen E, Carrondo MJ, Hauser H, Wirth D. Mol Ther. 2006